CONTACT

Are You a Patient?

Welcome to Endorenew. If you’re here, you might be looking for answers about two rare conditions affecting uterine health: Asherman syndrome and thin endometrium. We’re here to help you understand these conditions, answer your questions, and guide you toward our personalized PAULA therapy.

CONTACT

Understanding Asherman Syndrome and Thin Endometrium

What is Asherman Syndrome?

Asherman Syndrome happens when scar tissue develops inside the uterus. This can block the uterine cavity, leading to symptoms such as:

  • Irregular or absent periods
  • Difficulty getting pregnant
  • Recurrent miscarriages

It is often caused by uterine surgery, like a D&C (dilation and curettage), or as a result of infections.

What is Thin Endometrium?

Thin endometrium is a descriptive finding where the lining of the uterus (the endometrium) is thinner than expected for that point in the menstrual cycle or hormonal state. 
  • Can be temporary or reversible
  • Often related to low oestrogen, medications (like GnRH agonists), stress, or timing of the ultrasound
  • In fertility contexts, it usually means an endometrial thickness below what’s considered optimal for implantation (thickness < 7mm measured by transvaginal ultrasound around ovulation or embryo transfer)
 
This finding is often caused by Asherman syndrome, hormone imbalances, post-surgical damage (procedures like D&C or uterine ablation) or aging (natural decline in uterine functions over time).

Why These Conditions Matter

If you’re experiencing infertility or other reproductive challenges, you’re not alone. These conditions can feel overwhelming, but advanced treatments are available to restore uterine health and help you on your fertility journey.

PAULA Therapy

What Is PAULA Therapy?

PAULA therapy (Patient AUtologous endometriaL Advanced) is a cutting-edge, personalized treatment designed to:

  1. Restore uterine health
  2. Improve fertility for women with Asherman Syndrome or thin endometrium

It uses CD133+ stem cells, which are pending approval by the FDA and EMA, to rebuild and regenerate the uterine lining. PAULA treatment is clinically proven, and tailored to each patient.

Am I a Candidate for PAULA Therapy?

You might be a good candidate if you:

  • Have been diagnosed with Asherman syndrome or thin endometrium
  • Struggle with infertility or pregnancy loss related to these conditions
  • Want a safe and innovative solution for uterine health

Your doctor can guide you through the evaluation process to see if PAULA Therapy is right for you.

Why Choose PAULA Therapy?

PAULA therapy offers:

  • Is an innovative Advanced Therapy Medicinal Product (ATMP) for human use based on somatic cell therapy using your own cells. 
  • Clinically proven results to improve uterine health and fertility
  • Is in the process of being approved by FDA and EMA, ensuring safety and effectiveness

It’s a pioneering treatment backed by research and trusted by doctors worldwide.

What to Expect During PAULA Therapy

Here’s how the process works:

  1. Evaluation: Your doctor will assess your medical history and condition.
  2. Personalized Plan: A treatment plan will be created just for you.
  3. Stem Cell Application: The therapy is infused in a minimally invasive manner to restore your uterine lining.

Most patients report improvements within a few months, with minimal downtime.

FAQs